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J Pediatr Hematol Oncol ; 42(4): e240-e243, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31107369

RESUMO

Idiopathic pulmonary hemosiderosis is characterized by a triad of iron-deficiency anemia, hemoptysis, and radiographic diffuse lung infiltrates. However, the inconsistent initial presentation in children may cause a significant delay in diagnosis. Autoimmune reactivity seems to be the most acceptable theory of pathogenesis. We reported an 8-year-old boy presenting with a cough, fever, and difficulty breathing with a history of iron-deficiency anemia and an abnormal autoimmune response in the last 3 years. Perinuclear antineutrophil cytoplasmic antibodies were positive and chest computed tomography revealed patchy ground glass haziness. Bronchoalveolar lavage fluid showed hemosiderin-laden macrophages. The respiratory symptoms improved with oral corticosteroids.


Assuntos
Anticorpos Anticitoplasma de Neutrófilos/imunologia , Doenças Autoimunes , Autoimunidade , Diagnóstico Tardio , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/imunologia , Doenças Autoimunes/patologia , Criança , Hemossiderose/diagnóstico , Hemossiderose/imunologia , Hemossiderose/patologia , Humanos , Pneumopatias/diagnóstico , Pneumopatias/imunologia , Pneumopatias/patologia , Macrófagos/imunologia , Macrófagos/patologia , Masculino , Hemossiderose Pulmonar
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